Plaque Psoriasis Before and After Results | Otezla® (apremilast) for PsO
Indications
APPROVED USES Prescription Otezla®/Otezla XRTM (apremilast) is used for the treatment of:

Active Psoriatic Arthritis:

  • OTEZLA: Adult and pediatric patients 6 years of age and older and weighing at least 20 kg (44 lbs) with active psoriatic arthritis. Read more >
Approved Uses Prescription Otezla®/Otezla XRTM (apremilast) is used for the treatment of:

Active Psoriatic Arthritis:

  • OTEZLA: Adult and pediatric patients 6 years of age and older and weighing at least 20 kg (44 lbs) with active psoriatic arthritis.
  • OTEZLA XR: Adult and pediatric patients 6 years of age and older and weighing at least 50 kg (110 lbs) with active psoriatic arthritis.

Plaque Psoriasis:

  • OTEZLA/OTEZLA XR: Adult patients with plaque psoriasis who are candidates for phototherapy or systemic therapy.
  • OTEZLA: Pediatric patients 6 years of age and older and weighing at least 20 kg (44 lbs) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.
  • OTEZLA XR: Pediatric patients 6 years of age and older and weighing at least 50 kg (110 lbs) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.

Oral Ulcers Associated with Behçet’s Disease:

  • OTEZLA/OTEZLA XR: Adult patients with oral ulcers associated with Behçet’s Disease. Read less >

After just 4 months, you can see clearer skin and reduced itching and flaking

Otezla treats at
the source–from the inside

You are leaving the Otezla website

Do you wish to leave this site?

YES No
  • Human icon with mild to moderate plaque psoriasis
    Mild to Moderate Plaque Psoriasis
    My small plaques aren’t all over, but still bother me when they appear
  • Human icon with moderate to severe plaque psoriasis
    Moderate to Severe Plaque Psoriasis
    I have many visible, sometimes larger plaques that are uncomfortable
  • Moderate to Severe Plaque Psoriasis and Moderate to Severe Genital Psoriasis
    Human icon with plaque psoriasis in sensitive areas
    I have to deal with plaques “down there” or in sensitive areas
See what’s possible with Otezla, a pill that goes where topical treatments can’t

See before and after results by clicking here.

In a study of adults with mild to moderate plaque psoriasis,

>5x

more people saw clearer skin with less
redness and flaking

Out of 595 patients, 22% of those taking Otezla achieved clearer skin after just 4 months compared to 4% of those on placebo.
>2x

more people felt less itch to scratch

Out of 502 people, 43% of those taking Otezla experienced less whole body itching after 4 months compared to 19% of those on placebo.
2x

less scalp psoriasis (and no need to apply a messy topical)

Out of 411 people, 44% of those taking Otezla saw improvement in their scalp psoriasis after 4 months compared to 17% of those on placebo.

See the Otezla difference

Click and drag to see what results with Otezla could look like.*

Before and after photos of an Otezla® (apremilast) patient's scalp-tab1
Before and after photos of an Otezla® (apremilast) patient's scalp-tab1

*Not actual Otezla patients. These images are used for illustrative purposes to show possible
before and after effects of treatment for mild to moderate plaque psoriasis patients. Not
everyone responds to Otezla. Those who do may respond differently.

Plaque psoriasis may present differently on varying skin tones.

Otezla can also help kids and teens see clear or almost clear skin after 4 months.†

†Pediatric patients 6 years and older with moderate to severe plaque psoriasis.

For those who experience more widespread symptoms, clearer skin is possible

See before and after results by clicking here.

In a study of adults with moderate to severe plaque psoriasis,

>6x

more people saw clearer skin, so they could cover up less

Out of 844 people, 33% of those taking Otezla achieved clearer skin after 4 months compared to 5% of those on placebo.

In a study of adults with moderate to severe plaque psoriasis and moderate to severe plaque psoriasis of the scalp,

2x

more people felt less itch to scratch

Out of 279 people, 46% of those taking Otezla experienced less whole body itching after 4 months compared to 23% of those on placebo.
>3x

more people had less scalp psoriasis and left the hat at home

Out of 303 people, 43% of those taking Otezla saw improvement in their scalp psoriasis after 4 months compared to 14% of those on placebo.

See the Otezla difference

Click and drag to see results

Before and after photos of an Otezla® (apremilast) patient's scalp
Before and after photos of an Otezla® (apremilast) patient's scalp 

Actual Otezla patients. Not everyone responds to Otezla. Those who do may
respond differently.

Plaque psoriasis may present differently on varying skin tones.

We know it can be difficult when plaque psoriasis shows up in the last place you want it to…

More than half of people with psoriasis experience symptoms in their genital area at some point in their lives. This means itchy, cracked, dry skin in the places we feel it most: on the vulva, penis, scrotum, and the surrounding skin.

Otezla works from the inside to treat plaque psoriasis in places where topicals may be irritating

In a study of adults with moderate to severe plaque psoriasis and moderate to severe genital psoriasis,

2x

more people saw fewer dry, flaky patches in the most sensitive places

Out of 289 people, 40% of those taking Otezla achieved clearer skin in their genital area after 4 months compared to 20% of those on placebo.
>2x

more people had relief from itchiness
“down there”

Out of 243 people, 47% of those taking Otezla experienced less itching after 4 months compared to 20% of those on placebo.
  • Human icon with mild to moderate plaque psoriasis
    Mild to Moderate Plaque Psoriasis
    My small plaques aren’t all over, but still bother me when they appear
    See what’s possible with Otezla, a pill that goes where topical treatments can’t

    See before and after results by clicking here.

    In a study of adults with mild to moderate plaque psoriasis,

    >5x

    more people saw clearer skin with less redness and flaking

    Out of 595 patients, 22% of those taking Otezla achieved clearer skin after just 4 months compared to 4% of those on placebo.
    >2x

    more people felt less itch to scratch

    Out of 502 people, 43% of those taking Otezla experienced less whole body itching after 4 months compared to 19% of those on placebo.
    >2x

    less scalp psoriasis (and no need to apply a messy topical)

    Out of 411 people, 44% of those taking Otezla saw improvement in their scalp psoriasis after 4 months compared to 17% of those on placebo.

    See the Otezla difference

    Click and drag to see what results with Otezla could look like.*

    Before and after photos of an Otezla® (apremilast) patient's scalp-tab1
    Before and after photos of an Otezla® (apremilast) patient's scalp-tab1

    *Not actual Otezla patients. These images are used for illustrative purposes to show possible
    before and after effects of treatment for mild to moderate plaque psoriasis patients.
    Not everyone responds to Otezla. Those who do may respond differently.

    Plaque psoriasis may present differently on varying skin tones.

    Otezla can help kids and teens see clear or almost clear skin after 4 months.†

    †Pediatric patients 6 years and older with moderate to severe plaque psoriasis.

  • Human icon with moderate to severe plaque psoriasis
    Moderate to Severe Plaque Psoriasis
    I have many visible,
    sometimes larger plaques that are uncomfortable
    For those who experience
    more widespread symptoms,
    clearer skin is possible

    See before and after results by clicking here.

    In a study of adults with moderate to severe plaque psoriasis,

    >6x

    more people saw clearer skin, so they could cover up less

    Out of 844 people, 33% of those taking Otezla achieved clearer skin after 4 months compared to 5% of those on placebo.

    In a study of adults with moderate to severe plaque psoriasis and moderate to severe plaque psoriasis of the scalp,

    2x

    more people felt less itch to scratch

    Out of 279 people, 46% of those taking Otezla experienced less whole body itching after 4 months compared to 23% of those on placebo.
    >3x

    more people had less scalp psoriasis and left the hat at home

    Out of 303 people, 43% of those taking Otezla saw improvement in their scalp psoriasis after 4 months compared to 14% of those on placebo.

    See the Otezla difference

    Click and drag to see results.

    Before and after photos of an Otezla® (apremilast) patient's scalp-tab1
    Before and after photos of an Otezla® (apremilast) patient's scalp-tab1 

    Actual Otezla patients. Not everyone responds to Otezla. Those who do may respond differently.

    Plaque psoriasis may present differently on varying skin tones.

  • Human icon with plaque psoriasis in sensitive areas
    Moderate to Severe Plaque Psoriasis and Moderate to Severe Genital Psoriasis
    I have to deal with plaques “down there” or in sensitive areas
    We know it can be difficult when plaque psoriasis shows up in the last place you want it to…

    More than half of people with psoriasis experience symptoms in their genital area at some point in their lives. This means itchy, cracked, dry skin in the places we feel it most: on the vulva, penis, scrotum, and the surrounding skin.

    Otezla works from the inside to treat plaque psoriasis in places where topicals may be irritating

    In a study of adults with moderate to severe plaque psoriasis and moderate to severe genital psoriasis,

    2x

    more people saw fewer dry, flaky patches in the most sensitive places

    Out of 289 people, 40% of those taking Otezla achieved clearer skin in their genital area after 4 months compared to 20% of those on placebo.
    >2x

    more people had relief from itchiness “down there”

    Out of 243 people, 47% of those taking Otezla experienced less itching after 4 months compared to 20% of those on placebo.

Plaque psoriasis looks different for everyone, but no matter how often you face symptoms, Otezla can help.

Did you know? Scalp plaque psoriasis may be a sign of psoriatic arthritis. Let your doctor know if you’re experiencing joint pain and swelling.
Did you know? Scalp plaque psoriasis may be a sign of psoriatic arthritis. Let your doctor know if you’re experiencing joint pain and swelling.
Learn about Otezla for Psoriatic Arthritis
~5x saw reduced red/purple, flaky skin

more people saw reduced red/purple, flaky skin, so they could cover up less

In a study of mild to moderate plaque psoriasis, 22% of people taking Otezla achieved clearer skin after 4 months compared to 4% on placebo.

~6x more people achieved clearer skin

more people achieved clearer skin

In a study of moderate to severe plaque psoriasis, 33% of people taking Otezla achieved clearer skin after 4 months compared to 5% on placebo.

~2x more people felt less itch to scratch

more people felt less itch to scratch

In a study of mild to moderate plaque psoriasis, 43% of people taking Otezla experienced less whole body itching after 4 months compared to 19% on placebo.

~3x more people had less scalp psoriasis

more people had less scalp psoriasis and left the hat at home

In a study of moderate to severe scalp psoriasis, 43% of people taking Otezla saw improvement after 4 months compared to 14% on placebo.

See the Otezla difference

Before and after photos of Otezla® (apremilast) patients with plaque psoriasis
Before and after photos of Otezla® (apremilast) patients with plaque psoriasis

Click and drag to see results

Actual Otezla patients. Not everyone responds to Otezla. Those who do may respond differently.

Plaque psoriasis may present differently on varying skin tones.

Two woman at a brunch gathering

What to expect on Otezla

Find out about managing side effects, seeing results, and more.
GET THE DETAILS
Woman on her laptop, in bed

Patient stories

Otezla has made a difference in lives of people just like you.
DISCOVER HOW
Woman preparing for a doctor's appointment

Prepare for your appointment

Communication is key. Start the conversation.
PREPARE FOR YOUR APPOINTMENT

See the Otezla difference

Back-right
Back-left

Click and drag to see what results with Otezla could look like*

*Not actual Otezla patients. These images are used for illustrative purposes to show possible
before and after effects of treatment for mild to moderate plaque psoriasis patients.
Not everyone responds to Otezla. Those who do may respond differently.

Plaque psoriasis may present differently on varying skin tones.

Otezla can also help kids and teens see clear or almost clear skin after 4 months†

†Pediatric patients 6 years and older with moderate to severe plaque psoriasis.

Pay as little as $0*

Did you know you may be eligible to pay as little as $0 per month with the Otezla Co-Pay Program? For eligible, commercially insured patients, your co-pay can be applied to deductible, co-insurance, and co-payment,* and is available regardless of your income level.

Enroll Now

First-time co-pay card user? Find out more about how it works and how it can help.

No insurance? Learn about other ways you may be able to access Otezla as prescribed.

*For commercially insured patients only. Eligibility criteria and program maximums apply.
See AmgenSupportPlus.com/copay-terms for full Terms and Conditions.

Caregivers of kids and teens under 18 can contact Amgen® SupportPlus at
1-844-4OTEZLA (1-844-468-3952) to complete enrollment, Monday – Friday, 8 AM – 8 PM ET.
Hand holding copay card from Amgen® SupportPlus program
Hand holding copay card from Amgen® SupportPlus program

IMPORTANT SAFETY INFORMATION

Do not take Otezla 30 mg tablets or Otezla XR 75 mg extended-release tablets if you are allergic to apremilast or to any of the ingredients in Otezla/Otezla XR

Otezla/Otezla XR can cause serious side effects, including:

  • Allergic reactions, sometimes severe. Stop using Otezla/Otezla XR and call your healthcare provider or seek emergency help right away if you develop any of the following symptoms of a serious allergic reaction: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.
  • Severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla/Otezla XR may increase the risk of complications from having severe diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.
  • Depression. In clinical studies, some patients reported depression or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla/Otezla XR, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla/Otezla XR.
  • Weight loss. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla/Otezla XR. For children 6 years of age or older, their doctor should monitor their growth (height and weight). If they are not growing or gaining weight as expected, their doctor will decide if they should continue taking Otezla/Otezla XR.

Some medicines may make Otezla/Otezla XR less effective and should not be taken with Otezla/Otezla XR. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines.

The most common side effects include diarrhea, nausea, upper respiratory tract infection, tension headache, and headache. These are not all the possible side effects with Otezla/Otezla XR. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for the Full Prescribing Information for Otezla/Otezla XR.

APPROVED USES

Prescription Otezla® /Otezla XRTM (apremilast) is used for the treatment of:

Active Psoriatic Arthritis:

  • OTEZLA: Adult and pediatric patients 6 years of age and older and weighing at least 20 kg (44 lbs) with active psoriatic arthritis
  • OTEZLA XR: Adult and pediatric patients 6 years of age and older and weighing at least 50 kg (110 lbs) with active psoriatic arthritis.

Plaque Psoriasis:

  • OTEZLA/OTEZLA XR: Adult patients with plaque psoriasis who are candidates for phototherapy or systemic therapy.
  • OTEZLA: Pediatric patients 6 years of age and older and weighing at least 20 kg (44 lbs) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.
  • OTEZLA XR: Pediatric patients 6 years of age and older and weighing at least 50 kg (110 lbs) with moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.

Oral Ulcers Associated with Behçet’s Disease:

  • OTEZLA/OTEZLA XR: Adult patients with oral ulcers associated with Behçet’s Disease.

IMPORTANT SAFETY INFORMATION

Do not take Otezla 30 mg tablets or Otezla XR 75 mg extended-release tablets if you are allergic to apremilast or to any of the ingredients in Otezla/Otezla XR.

Otezla/Otezla XR can cause serious side effects, including:

  • Allergic reactions, sometimes severe. Stop using Otezla/Otezla XR and call your healthcare provider or seek emergency help right away if you develop any of the following symptoms of a serious allergic reaction: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.