Approved Uses

Otezla® (apremilast) is a prescription medicine used to treat adult patients with:

 
Otezla is for adult patients with
plaque psoriasis
Otezla for psoriatic arthritis
Otezla for oral ulcers
in Behçet’s Disease
SEE MORE

APPROVED USES

Otezla® (apremilast) is a prescription medicine used to treat adult patients with:

  • Plaque psoriasis for whom phototherapy or systemic therapy is appropriate.
  • Active psoriatic arthritis.
  • Oral ulcers associated with Behçet’s Disease.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause allergic reactions, sometimes severe. Stop using Otezla and call your healthcare provider or seek emergency help right away if you develop any of the following symptoms of a serious allergic reaction: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of complications from having severe diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

The most common side effects of Otezla include diarrhea, nausea, upper respiratory tract infection, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for the Full Prescribing Information for Otezla.

Results with Otezla for moderate to severe plaque psoriasis

You might be wondering how soon you may expect to see results. If Otezla works for you, you may notice results after 4 months of treatment.

A separate clinical study involved adults with mild to moderate plaque psoriasis.

Before & after pictures

Otezla has been proven to improve moderate to severe plaque psoriasis symptoms in commonly affected areas like the elbows, knees, lower back, and scalp. Below are pictures of people with moderate to severe plaque psoriasis, before and during treatment with Otezla.

Actual Otezla patients. Not everyone responds to Otezla, and those who do respond may respond differently.

Back
Picture of back affected with psoriasis before treatment
Picture of Otezla results on back affected with psoriasis after treatment
Legs
Picture of legs affected with psoriasis before treatment
Picture of Otezla results on legs affected with psoriasis after treatment
Elbow
Picture of elbows affected with psoriasis before and after treatment
Picture of Otezla results on elbows affected with psoriasis after treatment
Hand
Picture of hands affected with psoriasis before treatment
Picture of Otezla results on hands affected with psoriasis after treatment
Scalp
Picture of scalp affected with psoriasis before treatment
Picture of Otezla results on scalp affected with psoriasis after treatment
Ear
Picture of ear affected with psoriasis before treatment
Picture of Otezla results on ear affected with psoriasis after treatment
Nail
Picture of nails affected with psoriasis before treatment
Picture of Otezla results on nails affected with psoriasis after treatment

Results with Otezla for mild to moderate plaque psoriasis

You might be wondering how soon you may expect to see results. If Otezla works for you, you may notice results after 4 months of treatment.

clear skin pillclear skin pill

Over 5 times more people achieved clearer skin after 4 months of taking Otezla (22%) compared to placebo (4%).

clear skin pillclear skin pill

Over 4 times as many people achieved 75% clearer skin after 4 months of taking Otezla (33%) compared to placebo (7%).

clear skin pillclear skin pill

Twice as many people with mild to moderate plaque psoriasis who took Otezla (43%) achieved an improvement in whole body itch, compared to those taking placebo (19%).

pillpill

Otezla is the first and only pill for mild to moderate scalp psoriasis, with nearly 3 times as many people achieving clearer skin—44% of people taking Otezla saw improvement after 4 months vs 17% of those taking a placebo.

Mild psoriasis can feel like anything but mild to patients

In a US survey of 559 adults with plaque psoriasis, 56% of people with mild plaque psoriasis rated their own symptoms as moderate or even severe.

Many patients need more than just a topical treatment

clear skin pillclear skin pill

87% of people using topicals found their mild to moderate plaque psoriasis symptoms continued to persist despite treatment.*

*An online cross-sectional survey among 175 adult patients on prescription topicals for mild to moderate psoriasis.

Remember:

Even if your psoriasis is improving,
it’s still there. It’s important to keep taking
Otezla as prescribed.

 

Meet Jennifer
Jennifer’s plaque psoriasis symptoms made her self-conscious. With Otezla, she’s living differently.
$name
SEE MORE

*Certain restrictions apply.

APPROVED USES

Otezla® (apremilast) is a prescription medicine used to treat adult patients with:

  • Plaque psoriasis for whom phototherapy or systemic therapy is appropriate.
  • Active psoriatic arthritis.
  • Oral ulcers associated with Behçet’s Disease.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause allergic reactions, sometimes severe. Stop using Otezla and call your healthcare provider or seek emergency help right away if you develop any of the following symptoms of a serious allergic reaction: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of complications from having severe diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

The most common side effects of Otezla include diarrhea, nausea, upper respiratory tract infection, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for the Full Prescribing Information for Otezla.

Important Safety Information

See more

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of complications from having severe diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

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