*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

Treat plaque psoriasis differently

Treat psoriatic arthritis differently

FOR US AUDIENCES ONLY
SEE MORE

*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

Approved Uses

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

Important Safety Information

You must not take Otezla® (apremilast) if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla is associated with an increase in adverse reactions of depression. In clinical studies, some patients reported depression and suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, suicidal thoughts, or suicidal behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla in psoriasis clinical studies were diarrhea, nausea, upper respiratory tract infection, tension headache, and headache.

Side effects of Otezla in psoriatic arthritis clinical studies were diarrhea, nausea, and headache.

These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant, or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088. 1-800-332-1088.

Please click here for Full Prescribing Information.

Frequently Asked Questions About Otezla and Plaque Psoriasis

Whether you've recently started taking Otezla® (apremilast) or you're considering it, chances are, you've got some questions. Below, we've collected a few of the most frequently asked questions. Have a read through, and click the links below each section to learn more.

What is Otezla?

Otezla is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

Is Otezla a biologic?

No, Otezla is not a biologic.

How does Otezla work?

The exact way in which Otezla works in people with psoriasis or psoriatic arthritis is not completely understood. Based on laboratory studies, what is known is that Otezla blocks the activity of an enzyme inside the body called phosphodiesterase 4 (PDE4). PDE4 is found inside the inflammatory cells in the body, and is thought to affect the process of inflammation. By blocking PDE4 activity, Otezla is thought to indirectly affect the production of inflammatory molecules, helping to reduce inflammation inside the body. Click here to learn more, or watch the video below.

How can I advocate for my health?

You'll find more information about this on our Talk to Your Doctor page—but the video below might also help. It features people currently taking Otezla talking about how they advocate for their health.

How do I take Otezla?

When you first start Otezla, you will gradually increase your dose over the first 5 days until you reach your recommended dose. Otezla is a pill you take once in the morning and once at night, every day. People with severe kidney disease will take Otezla once a day.

This gradual increase over the first 5 days is meant to help reduce the gastrointestinal symptoms related to initial treatment with Otezla.

For your first day, you only take one pill.

Be sure to take Otezla as directed by your doctor.

What do I need to know about starting Otezla?

When you first start Otezla, you will gradually increase your dose over the first 5 days until you reach your recommended dose. Otezla is a pill you take once in the morning and once at night, every day. People with severe kidney disease will take Otezla once a day.

This gradual increase over the first 5 days is meant to help reduce the gastrointestinal symptoms related to initial treatment with Otezla.

For your first day, you only take one pill.

Be sure to take Otezla as directed by your doctor.

See how you can save on Otezla

What are the side effects of Otezla?

In clinical trials of patients with moderate to severe plaque psoriasis, the most common side effects were diarrhea, nausea, upper respiratory tract infection, tension headache, and headache. The majority of patients reporting nausea and diarrhea did so with the first 2 weeks of treatment, and these tended to resolve over time without stopping Otezla.

If you are experiencing side effects, you can call Otezla SupportPlus™ to speak with a nurse. Give us a ring at 1-844-4OTEZLA (1-844-468-3952). 1-844-4OTEZLA (1-844-468-3952).

And remember, your doctor is the best source of information for you. Talk to your doctor about any side effects that bother you or do not go away.

Learn more about the side effects of Otezla

Are there any resources to help me when I start treatment?

We know starting a treatment can mean a lot to keep track of. That’s why we’ve created the GOtezla® app, available for download on the App Store and Google Play. With symptom tracking, personalized tips, and more, the GOtezla app is designed to help you get the resources and support you need for the first 30 days of treatment—and beyond.

Remember, your doctor is always your best resource for any questions you might have about treatment.

Learn more about the GOtezla app

How can I hear from others about their decision to start Otezla?

You'll find stories from people currently taking Otezla on our Patient Stories page—or, you can check out the video below, which features people currently taking Otezla talking about their decision-making process in selecting Otezla as a treatment.

How might Otezla help me?

Studies showed, approximately 1 out of 3 people taking Otezla achieved 75% clearer skin after just 4 months—with a reduction in redness, thickness, and scaliness. Some of these people saw clear or almost clear skin.

Learn more about Otezla for plaque psoriasis

Are there certain medications I already take that could make Otezla less effective?

Yes, there are certain medications that can make Otezla less effective. It's important to discuss all the medications you're currently taking with your doctor. It may help to compile a list, and bring that list to your appointment. You can also ask a pharmacist if you should not take some medications with Otezla.

Has Otezla been studied in pregnant women or in women who are breastfeeding?

Otezla has not been studied in pregnant women, or in women who are breastfeeding. Tell your doctor if you are pregnant, planning to become pregnant, or planning to breastfeed.

How will I get my Otezla prescription?

Your Otezla prescription will come to you each month via a specialty pharmacy. Never worked with one before? Here's the deal: specialty pharmacies operate much like retail pharmacies, but they provide additional services, and deliver your medication to your door each month. Your specialty pharmacy will coordinate delivery of your Otezla prescription, and offer support, including access to pharmacists, refill reminders when you're running low on medication, and more.

Learn about getting your Otezla prescription

Is Otezla covered by my insurance?

For questions about eligibility and coverage, please call our SupportPlus™ team at 1-844-4OTEZLA (1-844-468-3952). 1-844-4OTEZLA (1-844-468-3952). Our advocates are available 8 am – 8 pm ET, Monday – Friday.

Learn more about Otezla SupportPlus™

How can I save on Otezla?

People with commercial insurance are eligible for a $0 co-pay* with the Otezla Savings Program. To take advantage of the savings available to you, ask your specialty pharmacy about the $0 co-pay offer, or give our SupportPlus™ advocates a call.

Regardless of what type of insurance (or lack of insurance) you have, we're committed to helping you find ways to save on treatment.

Learn about all the different ways to save on Otezla

*Eligibility restrictions apply. This offer is not valid for persons eligible for reimbursement of this product, in whole or in part, under Medicaid, Medicare, or similar state or federal programs. Offer void where prohibited by law. People who are not eligible can call 1-844-4OTEZLA1-844-4OTEZLA to discuss other financial assistance opportunities.

How can I make sure I'm getting the latest on Otezla?

To make sure you're getting all the latest information on Otezla, including savings offers, helpful tools to stay on track with treatment, and more, sign up for Otezla SupportPlus. To see how SupportPlus™ has helped people currently taking Otezla, check out the video below.

How can I help other people living with psoriatic disease?

If you're interested in being an Otezla Patient Ambassador, call 1-855-697-3968 1-855-697-3968. Telling your story is a great way to help others living with psoriatic disease. You can also get involved in local events, or online events. Find some in your area here. To see what others currently living with psoriatic disease have to say about raising awareness, check out the video below.

Otezla is a different kind of treatment Close

Approved Uses

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

SEE MORE

*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

Approved Uses

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

Important Safety Information

You must not take Otezla® (apremilast) if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla is associated with an increase in adverse reactions of depression. In clinical studies, some patients reported depression and suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, suicidal thoughts, or suicidal behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla in psoriasis clinical studies were diarrhea, nausea, upper respiratory tract infection, tension headache, and headache.

Side effects of Otezla in psoriatic arthritis clinical studies were diarrhea, nausea, and headache.

These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant, or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088. 1-800-332-1088.

Please click here for Full Prescribing Information.

Important Safety Information

See more

You must not take Otezla® (apremilast) if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla is associated with an increase in adverse reactions of depression. In clinical studies, some patients reported depression and suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, suicidal thoughts, or suicidal behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

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