Approved Uses

Otezla® (apremilast) is a prescription medicine approved for the treatment of adult patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

Otezla is a prescription medicine approved for the treatment of adult patients with oral ulcers associated with Behçet’s Disease.

 
Otezla for moderate to severe
plaque psoriasis
Otezla for psoriatic arthritis
Otezla for oral ulcers
in Behçet’s Disease
SEE MORE

*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of adult patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

Otezla is a prescription medicine approved for the treatment of adult patients with oral ulcers associated with Behçet’s Disease.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information for Otezla.

Otezla is the first and only FDA-approved pill for oral ulcers associated with Behçet’s Disease

In a clinical study, Otezla was proven to treat the oral ulcers associated with Behçet’s Disease

In some people, after just 12 weeks, Otezla was proven to:

  • Help reduce oral ulcers
  • Help reduce oral ulcer pain

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Common side effects of Otezla

Otezla was studied among 207 adults with oral ulcers associated with Behçet’s Disease.

The table below shows the most commonly reported side effects from people taking Otezla 30 mg twice daily, compared to those taking placebo (sugar pill).

*The titration period was days 1-5, during which the dose was gradually increased until the recommended dose of 30 mg twice daily was reached.

These are not all the possible side effects of Otezla. Tell your doctor about any side effect that bothers you or does not go away.

If you are experiencing side effects, please consult your doctor.

For more information, please see Important Safety Information to the right of this page.

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Ask your rheumatologist if Otezla is right for you

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Inflammation in Behçet’s Disease

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Although the exact role of inflammation in Behcet's Disease is unknown, it may play a part.

Behçet’s Disease is associated with inflammation inside the body. Lab research has shown that an enzyme called phosphodiesterase 4 (PDE4), located inside cells, contributes to the inflammation.

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How does Otezla work?

The exact way Otezla works in people with Behçet’s Disease isn’t completely understood, but here’s what we do know:

  • Otezla is a type of pill called a “PDE4 inhibitor”—meaning it works inside inflammatory cells to reduce PDE4 activity
  • Reducing PDE4 activity is thought to help reduce inflammation

Taking Otezla

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Otezla is the first and only FDA-approved treatment for oral ulcers associated with Behçet’s Disease

Otezla is a pill taken by mouth every day—once in the morning, and once at night. For example, you can take Otezla with breakfast and dinner each day, or when you wake up and when you go to bed at night. (On your first day, you only take one pill.) For people with severe kidney disease, Otezla is one pill a day.

  • Be sure to take Otezla as directed by your doctor
  • You can take Otezla with or without food. But don’t crush, split, or chew the pill

When you first start treatment, you’ll see you have a 5-day titration period, which means that you’ll gradually increase your dose over your first 5 days until you reach the recommended dose. People with severe kidney disease will follow a different schedule for their titration period.

 

This titration period is meant to help reduce the gastrointestinal symptoms related to initial treatment with Otezla.

Did you know?

Your Otezla prescription will be sent right to your doorstep each month. Questions? Call 1-844-4OTEZLA and ask about delivery from a specialty pharmacy.

What is Behçet’s Disease?

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Behçet’s Disease is a chronic inflammatory disease that can produce a variety of symptoms.

Because symptoms of Behçet’s Disease appear differently for different people, it can often be hard for doctors to diagnose.

One of the main symptoms associated with Behçet’s Disease is oral ulcers. Oral ulcers are usually painful, and can interfere with everyday functions like eating, drinking, and speaking.

Otezla is only approved to treat the oral ulcers associated with Behçet’s Disease, but there are other symptoms to be aware of. These can include genital ulcers, eye inflammation, skin lesions, joint pain, blood vessel inflammation, brain inflammation, and digestive tract ulcers.

Did you know almost all people diagnosed with Behçet’s Disease will experience oral ulcers?

Often, they’re the first symptoms people notice.

More resources

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Want more information about Behçet’s Disease?

If you’re interested in learning more, the following resources can help. Each organization has information for people living with Behçet’s Disease.

You can learn more by visiting their websites:

 

Otezla Supply and Support FAQs

Please consult with your physician if you have concerns about continuing Otezla during the COVID-19 pandemic.

Will my prescription shipments be delayed due to COVID-19?

Otezla is available through your specialty pharmacy. Otezla is shipped to your home via mail carriers. Currently, we do not anticipate any interruption in shipments/mail carriers.

Is there a supply shortage of Otezla?

Amgen continues to provide an uninterrupted supply of medicines for patients around the world. Based on inventory levels, we do not anticipate a shortage of our medicines due to COVID-19 at this time.

We are monitoring our raw material inventory levels and taking additional measures to minimize interruption.

If you have questions or concerns regarding your supply of Otezla, you should contact your specialty pharmacy or Otezla SupportPlusTM at 1-844-4-OTEZLA (1-844-468-3952).

Where should I go if I have a COVID-19–related question about Otezla or any Amgen medication I am taking?

If you have questions about your Amgen medication, you can reach us via phone in the US at 1-800-772-6436.

If you have any questions about your treatment plan because of concerns about COVID-19, it is important to consult with your doctor.

Can I still reach out to Otezla SupportPlusTM during this time?

Otezla SupportPlus™ will continue to provide services without interruption to ensure continuity of care of Otezla patients. SupportPlus has enacted a plan to have the majority of the staff work remotely.

Co-pay access and the Bridge Program will continue without interruption. New and active Bridge patients will receive an additional Bridge Pack to ensure minimal disruption as we seek prior authorization approvals.

You can continue to call 1-844-4-OTEZLA (1-844-468-3952) to speak to a SupportPlus team member from 8 AM – 8 PM ET, Monday-Friday.

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Savings and cost support

Most people with private insurance pay nothing out of pocket for their Otezla prescription. After you’re prescribed, you have the same opportunity to save.

 

How to get the $0 co-pay* offer:

More ways to save

  • If you have private insurance and are experiencing delays or your private insurance doesn’t cover Otezla, you may be eligible for free medication through the Otezla Bridge Program
  • If you have government-issued insurance (Medicare or Medicaid) or are uninsured/underinsured, you may be eligible for the Patient Assistance Program 
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For all Otezla savings and support questions:

Call 1-844-4OTEZLA (1-844-468-3952)

*Certain restrictions apply; eligibility not based on income, must be 18 years or older. This offer is not valid for persons eligible for reimbursement of this product, in whole or in part under Medicaid, Medicare, or similar state or federal programs. Offer not valid for cash-paying patients. People who are not eligible can call 1-844-4OTEZLA to discuss other financial assistance opportunities.

To receive a free bridge supply of Otezla, you must have an on-label diagnosis and be denied or experiencing a delay in obtaining coverage. Federal, State, or similar insurance plans are not eligible for Bridge. Once Otezla is approved by your commercial insurance plan, you will no longer be eligible for the Bridge Program.

Prescription

Sign up for support

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Information about paying for Otezla

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Track your progress with the free Otezla app

SEE MORE

*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of adult patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

Otezla is a prescription medicine approved for the treatment of adult patients with oral ulcers associated with Behçet’s Disease.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information.

Important Safety Information

See more

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

 

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